Products

Compound Librairies

Greenpharma and its brand Prestwick Chemical offer several types of libraries depending on your needs.

Our goal is that hits may be found whatever assays are performed.

To achieve this, we pay most attention to the careful selection of the compounds. Therefore, we propose several products according to your needs.

PRODUCTS

POSSIBLE USES
Greenpharma Natural Compound Library (GPNCL) Hit finding
Greenpharma Ligand Library (LIGENDO) Hit finding, receptor “deorphanisation”, chemogenomic
Greenpharma Plant Extract Library (GPEL) Hit finding (synergistic mixtures) and new scaffold identification
Prestwick Chemical Library (PCL) Drug repurposing/repositioning
Prestwick Phytochemical Library (PPL) Hit finding and drug repurposing/repositioning
Other Prestwick Chemical Libraries Hit finding for specific targets or domains

We can also develop customised compound libraries on demand.

Greenpharma Natural Compound Library (GPNCL)

The Greenpharma natural chemical library combines our expertise in computational and medicinal chemistry, and our knowledge in pharmacognosy to create a unique source of diverse and pure compounds for hit/lead discovery. To built GPN, we gathered 450,000 natural compound structures in a database and used chemoinformatic tools to select a subset of chemically diverse and drug-like compounds.

We discarded amino acids, peptides, nucleic acids, long fatty chains, metals. We, then, carefully selected different phytochemical families in order to have as much family representatives as possible. A stock is maintained for each molecule to ensure further resupplies. GPN compounds are certified genuine natural compounds and information about the sources (e.g. family, genus, species, organ) are provided.

Applications

Hit & lead discovery, chemogenomics

Benefits

Large chemical diversity, drug-like molecules, possibility of resupplies.

Library technical characteristics

Each microplate of this library is populated with 80 products. Each well contains 500µL (or 20µL) of a DMSO solution at 5mM of the products. This high concentration easily allows dilutions up to micromolar concentrations without the side toxicity effect of DMSO.

  • Purity above 90 %
  • Chemical diversity
  • Drug-likeness
  • User-defined formatting in option

Data provided

The library is supplied with an electronic file (e.g. SDF, XLS & PDF format) containing the structure, the name, the position of each product in the microplate, examples of natural sources producing the compounds and calculated physico-chemical descriptors.

Physico-chemical properties and phytochemistry distribution

The following table shows the physico-chemical profile and the phytochemistry distribution of GPNCL. Alkaloids are  predominant as they represent a large and diverse phytochemical family followed by terpenes.

Greenpharma Ligand Library (LIGENDO)

LIGENDO combines Greenpharma expertise in computational and medicinal chemistry, and its knowledge in natural products to create a unique source of diverse and pure compounds for chemogenomics or ‘biological pathway hopping’. These 400 Human endogenous ligands are selected by molecular diversity.

A stock is maintained for each molecule to ensure further resupply. GPLL compounds are certified genuine natural compounds.

Applications

Hit & lead discovery, chemogenomics, drug repositioning, pathway hopping…

Benefits

Chemical diversity, metabolites, possibility of resupplies, biological pathway knowledge, bio-property predictions.

Library technical characteristics

Each microplate of this library is populated with 80 products. Each well contains 1mL (or 20µL) of a DMSO solution at 1mg/mL of the products. Taking into account the average molecular weight, we estimate at about 5.10-3 M the concentration in each well. This high concentration easily allows dilutions up to micromolar concentrations without the side toxicity effect of DMSO.

  • Purity above 90 %
  • Chemical diversity
  • Metabolite-like
  • User-defined formatting in option

Supplied data

A database is supplied with GPLL. It describes the content of each well i.e. the name of the compound, its structure, the metabolic pathway implied, EC number of proteins that interact with the molecule, calculated physico-chemical properties and putative protein interacting partners identified by Selnergy™, our in-house inverse docking tool.

Physico-chemical properties

This library includes hormones, vitamins or precursors & co-factors, peptidic derivatives, fatty acids and carbohydrates (see hereafter the physico-chemical profile)

Extract Library (GPEL)

The Greenpharma extract library is a plant extract library which combines Greenpharma expertise in natural source products, and its knowledge in pharmacognosy to create a unique source of diverse and original extracts for screening and lead discovery.

The GPE includes know-how in ethnobotany, botany, pharmacology, pharmacognosy, organic chemistry and analytical chemistry to present a variety of extracts as wide as possible. The selection procedure is based on biotope and taxonomic diversity. Moreover, a “patentability” criteria is added to ensure the originality of the selected plants. Each plant is stocked so that resupply is possible within a short delay.

Applications

Hit & lead discovery, botanicals discovery.

Benefits

Chemodiversity reflected in the biodiversity, potential source of new scaffolds.

Library technical characteristics

GPE is presented in a format suitable for HTS. A microplate contains 80 extracts representing 20  plants, each of them being represented by 4 different polarity solvent fractions. Each well includes 2 mg of extract diluted in 200 µL of DMSO. This high concentration easily allows dilutions in order to avoid the side toxicity effect of DMSO.

Supplied data

A file is supplied with the extract library (e.g. XLS, PDF). It describes the content of each well and includes information about the plant family, genus, species, organ and ethnobotanic data.

Distribution

We selected the plants by biodiversity to cover a maximum of taxons from different environments. Thus in the 200 plant species, there are 187 genus corresponding to 80 families.

Prestwick Chemical Library (PCL)

This library contains 1520 FDA-approved & EMA-approved drugs for HTS and HCS screening.

This diversified marketed drugs library targets more than 600 enzymes/receptors and is designed for repurposing/repositioning.

Click here for more details.

Prestwick Phytochemical Library (PPL)

This library is composed of a set of small molecules from natural origin and represents a unique source of natural and purified compounds with drug-like features for hit/lead discovery.

Click here for more details

Other Prestwick Chemical Libraries

Prestwick Chemical, a brand of Greenpharma, also offers other specific libraries for your research, such as:

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